Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonistsSALVATI, Mark E; BALOG, Aaron; KRYSTEK, Stanley R et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 2, pp 271-276, issn 0960-894X, 6 p.Article

Discovery and development of 5-[(5S,9R)-9-(4 -Cyanophenyl )-3-(3,5 -dichlorophenyl )-1-methyl -2,4 -dioxo-1,3,7 -triazaspiro [4.4 ]non-7 -yl -methyl ] -3-thiophenecarboxylic Acid (BMS-587101) : A small molecule antagonist of leukocyte function associated antigen-1POTIN, Dominique; LAUNAY, Michele; BESSE, Dominique et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 24, pp 6946-6949, issn 0022-2623, 4 p.Article

7-Oxopyrrolopyridine-derived DPP4 inhibitors—mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active siteWEI WANG; DEVASTHALE, Pratik; WEIGELT, Carolyn et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 22, pp 6646-6651, issn 0960-894X, 6 p.Article

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitorsDYCKMAN, Alaric J; TIANLE LI; KISH, Kevin et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 15, pp 4633-4637, issn 0960-894X, 5 p.Article

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994) : A potent and efficacious p38a MAP kinase inhibitorHYNES, John; HONG WU; MCINTYRE, Kim W et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 6, pp 1762-1767, issn 0960-894X, 6 p.Article

Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitorsYAN SHI; O'CONNOR, Stephen P; KLEI, Herbert E et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 24, pp 7516-7521, issn 0960-894X, 6 p.Article

5-Amino-pyrazoles as potent and selective p38α inhibitorsDAS, Jagabandhu; MOQUIN, Robert V; NEWITT, John A et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 23, pp 6886-6889, issn 0960-894X, 4 p.Article

Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitorsYAN SHI; JING ZHANG; KISH, Kevin et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 15, pp 4034-4041, issn 0960-894X, 8 p.Article

Benzothiazole based inhibitors of p38α MAP kinaseCHUNJIAN LIU; LIN, James; TRZASKOS, James et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 6, pp 1874-1879, issn 0960-894X, 6 p.Article

Image Annotation and Database Mining to Create a Novel Screen for the Chemotype-Dependent Crystallization of HCV NS3 Protease: Published as part of the Crystal Growth & Design virtual special issue on the 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13)KLEI, Herbert E; KISH, Kevin; RUSSO, Mark F et al.Crystal growth & design. 2011, Vol 11, Num 4, pp 1143-1151, issn 1528-7483, 9 p.Article

Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa InhibitorsYAN SHI; SITKOFF, Doree; YOUSSEF, Sonia et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7541-7551, issn 0022-2623, 11 p.Article

X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavirKLEI, Herbert E; KISH, Kevin; SHERIFF, Steven et al.Journal of virology. 2007, Vol 81, Num 17, pp 9525-9535, issn 0022-538X, 11 p.Article

The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutantsTOKARSKI, John S; NEWITT, John A; DIANLIN XIE et al.Cancer research (Baltimore). 2006, Vol 66, Num 11, pp 5790-5797, issn 0008-5472, 8 p.Article

Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymeraseGENTLES, Robert G; SHERIFF, Steven; MORIN, Paul et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 8, pp 2212-2215, issn 0960-894X, 4 p.Article

Phenyltriazolinones as potent factor Xa inhibitorsQUAN, Mimi L; PINTO, Donald J. P; SMALLWOOD, Angela et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 4, pp 1373-1377, issn 0960-894X, 5 p.Article

Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577YAN SHI; CHI LI; KLEI, Herbert E et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 24, pp 6882-6889, issn 0960-894X, 8 p.Article

Pyrazolo-pyrimidines : A novel heterocyclic scaffold for potent and selective p38α inhibitorsDAS, Jagabandhu; MOQUIN, Robert V; KIEFER, Susan E et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 8, pp 2652-2657, issn 0960-894X, 6 p.Article

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)SULSKY, Richard; MAGNIN, David R; HARRITY, Thomas et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 12, pp 3511-3515, issn 0960-894X, 5 p.Article

Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitorsSHUQUN LIN; WROBLESKI, Stephen T; KIEFER, Susan E et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 19, pp 5864-5868, issn 0960-894X, 5 p.Article

Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator : Potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in ratsOSTROWSKI, Jacek; KUHNS, Joyce E; SLEPH, Paul G et al.Endocrinology (Philadelphia). 2007, Vol 148, Num 1, pp 4-12, issn 0013-7227, 9 p.Article

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitorsWROBLESKI, Stephen T; SHUQUN LIN; DOWEYKO, Arthur M et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 8, pp 2739-2744, issn 0960-894X, 6 p.Article

N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore ReorientationNIRSCHL, Alexandra A; YAN ZOU; BEEHLER, Blake C et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 9, pp 2794-2798, issn 0022-2623, 5 p.Article